Past Trials

AFFINITY

Assessment of fluoxetine in stroke recovery trial Lead PI:  Prof Graeme J Hankey and A/Prof Maree L. Hackett Status: Closed No….

ASSENT

A Phase 1b/2, Multi-Centre, Double-Blind, Placebo-Controlled, Randomized, Single-Ascending Dose Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of DS-1040b in…

ATTUNE

ATrial fibrillation in sTroke; Utility of Neuroimaging Evaluation Lead PI: Prof Mark Parsons Status: Recruiting No. of Patients Currently Recruited: 256                                No. of Patients…

AVERT

A Very Early Rehabilitation Trial AVERT is a Phase III, international, multicentre, single blind trial comparing earlier onset and higher…

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AVERT DOSE

A trial to Determine the Optimal early mobility Training after Stroke AVERT DOSE: A trial to Determine the Optimal early…

AXIOMATIC-SSP

A Study of BMS-986177 for the Prevention of a Stroke in Patients Receiving Aspirin and Clopidogrel AXIOMATIC-SSP: A Study of…

CHARM

Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicentre, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe…

COMPARE

Constraint Induced or Multi-Modal aphasia rehabilitation: A Randomised Controlled Trial (RCT) for stroke related chronic aphasia Lead PI: A/Prof Miranda Rose Status: Completed…

DIRECT-SAFE
DIRECT-SAFE

A randomised controlled trial of DIRECT endovascular clot retrieval versus standard bridging thrombolysis with endovascular clot retrieval within 4.5 hours…

ESCAPE NA-1

A Multicentre, Randomised, Double-blinded, Placebo-controlled, Parallel Group, Single-dose Design to Determine the Efficacy and Safety of Intravenous NA-1 in Subjects…

ESCAPE-Next
ESCAPE-Next

A Multicentre, Randomized, Double-blinded, Placebo-controlled, Parallel Group, Single-dose Design to Determine the Efficacy and Safety of Nerinetide in Participants with…

EVACUATE
EVACUATE-RCT

Ultra-Early, Minimally inVAsive intraCerebral Haemorrhage evacUATion Versus Standard trEatment Lead PI: Prof Timothy Kleinig Status: ASTN endorsed, Site selection, Recruiting…

EVIP

Early Vocational Intervention of People after Stroke: A Randomised Pilot Trial Lead PI: Prof Natasha Lannin Status: Recruiting No. of Patients Currently…

EXTEND

Extending the time for Thrombolysis in Emergency Neurological Deficits Phase III, randomised, multicentre, double blinded, placebo controlled trial (2 arm…

EXTEND-IA DNase

Improving early reperfusion with adjuvant dornase alfa in large vessel ischemic stroke. An umbrella Bayesian optimized phase 2 trial of…

EXTEND-IA TNK

Extending the time for thrombolysis in emergency neurological deficits – intra-arterial with tenecteplase Lead PI: Dr Bruce Campbell Status: Closed  No. of…

INSPIRE

INternational Stroke Perfusion Imaging Registry INSPIRE: INternational Stroke Perfusion Imaging REgistry Lead PI:  John Hunter Hospital Status: Closed No. of Patients…

INTERACT3
INTERACT3

INTEnsive care bundle with blood pressure Reduction in Acute Cerebral haemorrhage Trial Lead PI:  Prof. Craig Anderson Status: Recruiting No. of…

MAEStro

A Randomized, Double-Blind, Placebo-Controlled,Dose-Response Efficacy and Safety Study of MLC1501 in Patients with Stroke   Lead PI: A/Prof Christopher CHEN…

MASTERS-2
MASTERS-2

MultiStem Administration for Stroke Treatment and Enhanced Recovery Study Lead PI: N/A Status: Site Selection No. of Patients Currently Recruited: 0                               No. of Patients…

MIDAS 2

Modafinil In Debilitating Fatigue After Stroke 2 Lead PI: Prof Chris Levi and Dr Andrew Bivard Status:  Recruiting  No. of…

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OCEANIC STROKE

A multicenter, international, randomized, placebo controlled, double-blind, parallel group and event driven Phase 3 study of the oral FXIa inhibitor…

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OCEANIC-AF

A multicenter, international, randomized, active comparator-controlled, double-blind, double-dummy, parallel-group, 2-arm, Phase 3 study to compare the efficacy and safety of…