Current Trials

Below are a list of trials currently endorsed by the ASTN. You can click on the trial tags to help streamline your search

Screenshot 2025-03-04 at 14.15.47
ASPIRING

  Antiplatelet Secondary Prevention International Randomised study after INtracerebral haemorrhaGe Background: Survivors of stroke due to spontaneous intracerebral haemorrhage (ICH)…

ATTUNE

ATrial fibrillation in sTroke; Utility of Neuroimaging Evaluation Lead PI: Prof Mark Parsons Status: Recruiting No. of Patients Currently Recruited: 256                                No. of Patients…

avert dose logo revised
AVERT DOSE

A trial to Determine the Optimal early mobility Training after Stroke AVERT DOSE: A trial to Determine the Optimal early…

Screen Shot 2022-05-18 at 3.14.34 pm
CASPER

CASPER: Colchicine After Stroke to Prevent Event Recurrence Chief Investigator A: Prof. Anthony Keech, NHMRC Clinical Trial Centre Chief Investigator…

CHARM

Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicentre, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe…

DIRECT-SAFE
DIRECT-SAFE

A randomised controlled trial of DIRECT endovascular clot retrieval versus standard bridging thrombolysis with endovascular clot retrieval within 4.5 hours…

Screenshot 2025-03-04 at 14.08.20
ECHOES-AF

Evaluating Cerebral micro-bleeding cHanges to Optimise anticoagulation thErapy in Stroke patients with Atrial Fibrillation Lead PI: Dr. Zien Zhou No. of…

ESCAPE-Next
ESCAPE-Next

A Multicentre, Randomized, Double-blinded, Placebo-controlled, Parallel Group, Single-dose Design to Determine the Efficacy and Safety of Nerinetide in Participants with…

EVACUATE
EVACUATE-RCT

Ultra-Early, Minimally inVAsive intraCerebral Haemorrhage evacUATion Versus Standard trEatment Lead PI: Prof Timothy Kleinig Status: ASTN endorsed, Site selection, Recruiting…

EVIP

Early Vocational Intervention of People after Stroke: A Randomised Pilot Trial Lead PI: Prof Natasha Lannin Status: Recruiting No. of Patients Currently…

INTERACT3
INTERACT3

INTEnsive care bundle with blood pressure Reduction in Acute Cerebral haemorrhage Trial Lead PI:  Prof. Craig Anderson Status: Recruiting No. of…

Screenshot 2025-03-11 at 15.39.34
LOTUS

Low dOse combinaTions to improve stroke oUtcomeS (LOTUS) Lead PIs: Dr Sonali Gnanenthiran, Prof Anthony Rodgers, Prof Timothy Kleinig, A/Prof Seana…

MAEStro

A Randomized, Double-Blind, Placebo-Controlled,Dose-Response Efficacy and Safety Study of MLC1501 in Patients with Stroke   Lead PI: A/Prof Christopher CHEN…

MASTERS-2
MASTERS-2

MultiStem Administration for Stroke Treatment and Enhanced Recovery Study Lead PI: N/A Status: Site Selection No. of Patients Currently Recruited: 0                               No. of Patients…

MIDAS 2

Modafinil In Debilitating Fatigue After Stroke 2 Lead PI: Prof Chris Levi and Dr Andrew Bivard Status:  Recruiting  No. of…

Screen Shot 2023-01-04 at 9.40.16 am
OCEANIC STROKE

A multicenter, international, randomized, placebo controlled, double-blind, parallel group and event driven Phase 3 study of the oral FXIa inhibitor…

OPTIMISTmain
OPTIMISTmain

Optimal Post rTpa-Iv Monitoring in Ischemic Stroke Lead PI: Professor Craig Anderson Status: Recruiting, Site selection No. of Patients Currently Recruited: 18 …

PESTO

 A Prospective multicentre, phase 2b randomised controlled double-blind trial, to determine the safety and efficacy of perispinal etanercept on quality…

POST-ETERNAL Logo
POST-ETERNAL

Extending the time window for Tenecteplase by Effective RecanalizatioN of bAsilar artery occLusion in patients with POSTerior circulation stroke Lead PI:  Dr Fana Alemseged Participating…

Screen Shot 2023-04-12 at 1.24.16 pm
QASC Australia

QUALITY IN ACUTE STROKE CARE (QASC) AUSTRALIA TRIAL Principal Investigator: Prof Sandy Middleton The Quality in Acute Stroke Care (QASC)…

RECAPS
ReCAPS

Recovery-focused Community support to Avoid readmissions and improve Participation after Stroke ReCAPS: Recovery-focused Community support to Avoid readmissions and improve Participation…

siciario logo on poster
SICARIO

Expanding stroke therapy access: Stroke in patients with large ischemic core Co-Principal Investigator: Prof Chris Levi Co-Principal Investigator: Dr Carlos…